OpsBug

Notes from a physician-scientist with too many tabs open.

Deep Dives

• Generalizing GRAFT to A Second Program From the Same Library

  Published:Nov 8, 2026 |  at 06:00 PM

  A new agent took the PhenoAge library and compiled a second clinical program (10-year mortality risk) into the same model

• Repeatable Weight Space Programming

  Published:Nov 8, 2026 |  at 05:00 PM

  Two Claude Opus agents built GRAFT, a set of reusable weight-space surgeries, and used it to compile Levine's PhenoAge formula into Qwen3-0.6B-Longevity with no gradient descent and no-human-in-the-loop.

• Exploring Weight-Space Programming for Longevity Models

  Published:Nov 4, 2026 |  at 03:00 AM

  Over five rounds, Claude Opus 5.5 edits Insilico Medicine's open aging model directly, with no training, until it ties a tuned classical model trained on the same data.

Brief Notes