OpsBug

Notes from a physician-scientist with too many tabs open.

Deep Dives

• Part 3: GRAFT, a Common Language for Programming Model Weights

  Published:Nov 8, 2026 |  at 06:00 PM

  What it would take for other people to write grafts too: a definition of the smallest valid graft, a file format, rules for combining grafts and a certificate format. It also reports that the library transfers: a fresh agent compiled a second program, 10-year mortality risk, with held-out error of 1.02 percentage points.

• Repeatable Weight Space Programming

  Published:Nov 8, 2026 |  at 05:00 PM

  Two Claude Opus agents built GRAFT, a set of reusable weight-space surgeries, and used it to compile Levine's PhenoAge formula into Qwen3-0.6B-Longevity with no gradient descent and no-human-in-the-loop.

• Exploring Weight-Space Programming for Longevity Models

  Published:Nov 4, 2026 |  at 03:00 AM

  Over five rounds, Claude Opus 5.5 edits Insilico Medicine's open aging model directly, with no training, until it ties a tuned classical model trained on the same data.

Recent Notes